Other than Marquez.

cant really think of any.
Morales did it In there 1st fight
I think,to beat manny you must have a really good chin, very good counter puncher, and ready to go for broke.
if you focus to potshot you will lose round againts him,
If you went toe to toe againts him you will end up like morales 2-3 when he capitalize on that right hook or end up like bradley 2
if you went runing forward you will end up like margarito
If you went running youp end up like cotto/Mosley
If you stay on defense youl end up like clotey

 

Larios did pretty good against pacquaio.
Margaritos size played a big role in pacquaio being in a fetus position after the fight.
Bradley in the rematch fought well, and lost a close fight.
Agapito sanchez was a tough, dirty gritty fight.

And a few others early on in his career.

 

Erik Morales troubled him as did Torrecampo and Singsurat

 

I dunno, there is no bigger way of giving someone trouble than by beating them correct?

 

The early defeats mean **** all like.

He was 7 stone **** wet through.

Imo the marquez and morales (once) troubled pacquiao

 

Other than Marquez (and others that beat him), Skinny Hussein

 

Hussein Nadal put Pac down with a jab, Pac was crossed eyed as a result. He was huge trouble.

 

But i think todays pac dirty tactics wont work any more
He is much more better fighter now unlike when he was at flyweigth and bantamweight
he is like a pancho villa back then. But short tempered he gets frustrated fast in his earlier career