Yes I know he'd be a cruiseweight by today's standards but I'd go with Marciano, especially considering he fought in the 15 round era. The guy rarely stopped coming forward Frazier might be a close 2nd as he too was relentles and I'm not talking about Marvis. Who ya got?
In no particular order, Jeffries, Norton, Ali (especially the 1960s, pre-banned version), Marciano, Holyfield (especially when he was “Evan Fields”), Norton, Frazier, Jack Johnson, and Joe Louis. I’m sure there are many others I am missing.
Frazier, he walked through everything the greatest heavyweight of all time threw at him for 15 rounds and won.
Usyk's training regime tells you a lot, he literally does 15x5 minute rounds (something crazy like that) with like 30/45 second rests. Each time Uysk finishes a fight on points he seems like he can do a few more rounds pretty comfortably, his engine is ridiculous and it is one of the reasons why Fury completely faltered in the second half of both of their fights. Have to give a special mention to Joe Frazier. Threw bombs constantly for 15 rounds.
These old guys aren't real HW's by today's standards so it's unfair to compare them. They're often LHW's and Cruisers until they get fat. Smaller fighters have better engines in general it's just a physical reality of not needing to supply a huge body. So if we're talking 'modern HW' fighters and talking about endurance whether natural or due to fitness conditioning, it's going to be Fury and Usyk, who I would say clearly have the best stamina. Usyk was a cruiser but a big one and bigger than most of these old HW's. Fury is bigger than Usyk and with similar stamina so I would say he has the best natural endurance of any HW ever, especially when you consider he's always fat. It's likely no coincidence they both aren't big power punchers either as it's often one of the other. That's another reason why 'Sugar Hill' clearly has zero understanding of basic things in physical/athletic performance. It was obvious Fury was an endurance athlete from early days and trying to turn him into a KO artist was never going to work properly. Notice no idiot ever tried to turn Usyk into one, but just improved his strengths.