Cotto, needs to fight him in the inside and outside....demonstrating versatility. He knows that a fashionable win most be seen to remove the negative perception From the Margarito fight.
I've picked Mayorga from the beginning by stoppage. He's a nut job, and considerably bigger than Cotto. But it really depends which Mayorga shows up that night. If the guy who fought Mosley tooth and nail for 11 rounds fights Cotto, I think it won't be a good night for Miguel. If not, Cotto should out-class him and outpoint him. I'll be rooting for Cotto.
If that's the way you feel then you should put some money down on Mayorga considering Cotto is such a heavy favorite.