I think there's a difference between being one-handed and not having to use both hands to their full extent, Mayweather is just that good a counter-puncher!
Juan Manual Marquez Ricky Hatton II Amir Khan Frankie Gavin Floyd Mayweather 30 year old Shane Mosley 40 year old Mike Tyson
Out of interest are you surprised by the amount of sucess Arguello had? All things considered he was up against it, and now you mentioning a major style diadvanatage, surely Arguello fought better than you anticipatd. As much as I am a fan of JMM I can't see it happening, but I'll be willing him on the whole way.
I was just a kid then, but I remember even then expecting that Alexis would outclass him because of the skill and experience factor. I'm not sure he can defeat him either at this point, but there are some things favoring him -he is a live underdog, he knows how to cope with Pacquiao's style, and he can be expected to give every ounce of himself to win.