Floyd wouldn’t figure him out, pluse he’d be at a physical disadvantage. Not as quick with foot or body movement, and not enough output to trouble him.
As Adam Smith said at the weekend, Lomachenko is a "well oiled fighter". he probably was the one that wanted to be doing the oiling but that's not the point.
The thing is though Floyd is a master at picking fighters off with that right hand. Given his height and reach advantage I could see him hitting Lomachenko at will with his right down the pipe. Those eye catching shots win him rounds even though he gets out worked.