Fights that ruined a fighter's career, win or lose?

A young Hearn's ended Saensak Muangsurin in numerous ways, including helping his eyesight deteriorate even further no doubt.

He also detached the retina of Ray Leonard. Not a guy you want to be hit by.

 

Also can't forget Hearns/Barkley II

Roy Jones terrible beating of Lacy was in my opinion at least as bad as the Calzaghe drubbing.

 

Iron mike tyson and razor ruddock 2 fights .

 

Set him back, certainly. But ruined his career? Far Far to early to tell, it may be the kick up the arse he needed. Time will tell

 

Razor ruddock was not the same after the two brutal Tyson fights

 

I don't get why some mention Dawson, when will people learn, that he actually never was that good?
A great example is Froch-Abraham. AA still had his confidence when he lost to Andre Dirrell which exposed him. But the one sided beatdown that Froch gave him was just to much. You could clearly see in his eyes that he was a completely broken man after that fight.
After the Maidana fight, i think Ortiz regained his confidence, but Mayweather took it away from him in his next fight.