Charlie Magri took one in the throat when he won his World Title. I remember getting one there myself. It's actually a very nasty blow.
Wilder is a notorious rabbit puncher. The neck is just part of it. Know he also openly admitts that he aim to cheat.
Go for the knees....that's always a good way to end a fight. Fury's knees are about 4' off the floor...shouldn't be illegal to hit knees that are above most peoples' waists.