He's definitely not without a chance mate. He had a lot going for him. A lot depends on how Bowe reacts to Tyson coming out like a bloody tornado, If he decides to stand and trade. We might see how the fight is going to play out in those very early rounds.
Bowe would be the toughest fighter Tyson ever fought in his prime. Bowe is significant margins better than Buster Douglas or even the Holyfield who beat Tyson in the mid/late 90s. It would be tough for Bowe, I reference the Herbie Hide fight and Hide was knocked out but able to land huge shots on Bowe consistently--Bowe was just too tough and strong and it didn't do much to him. Tyson would hit a lot harder than Hide. The question is whether Bowe would be as available to hit as he was for that fight. I can't say.
Bowe was a dirty fighter when things got tough. I think he does a lot of clinching and tying up Tyson to stop the onslaught. Pushing down on his head like Ali did with Frazier. Trying to use his size and weight to lean on Tyson and tire his legs.