I go with Holmes by late round stoppage, but I do think Patterson with his speed could dominate some of the exchanges with his superior hand speed. Holmes is about the size of Liston, but not as powerful a puncher, so I doubt a blowout. But I do think Holmes would dominate most of the fight and perhaps floor Patterson with a right cross late in the fight. Patterson gets up and Holmes traps him on the ropes and pummels him with right hand after right hand, the ref steps in and stops the fight.