Margo with legal wraps or ilegal wraps...vargas before or after fighting Tito those two facts could make a difference
Margo will be walking into shots all night. Vargas was a very good fighter at his best and fought some pretty good pressure fighters. I think Vargas will force Margo to respect his power. I think Margo's chin will hold up but I just see Vargas landing more punches and landing more cleanly throughout the fight.
He already specified a prime Vargas. So, assume the best version. Vargas knocks Margarito out at 154lbs.
Vargas had sick skills at his peak. The only man to decisively beat Ike Quartey would have little problems in outboxing and possibly getting a TKO against Margo.