Best run of title defences vs quality opponents?

Oscar De La Hoya has to be in this discussion.

Rafael Ruelas 43-1
Genaro Hernandez 32-0
Jesse James Leijas 32-1
Julio Cesar Chavez 96-1
Miguel Gonzalez 41-0
Pernell Whitaker 40-1

That's quite list to fight one after the other.

 

It was a good run. Not to nitpick, though, but two of those weren't defenses. He moved up to beat Chavez for his title and moved up to defeat Whitaker for his.

 

Eusebio Pedroza

Haglers middleweight title defense run is very impressive too.

 

Froch v...

Pascal
Taylor
Dirrell
Kessler
Abraham
Johnson
Ward
Bute

 

Alexis Arguello at 130

 

Sanchez: Lopez (rematch), Gomez, LaPorte and Nelson.

 

Ali during his first run defended against...
Sonny Liston
Floyd Patterson
Chuvalo
Cooper
London
Mildenberger
Williams
Terrel
Folley


Nonito Donaire during his p4p rise...
Beat Fernando Montiel 44-2-2 with 34 KO's, number 1 fighter at Bantamweight
Omar Narvaez, 35-0 and the number 1 fighter at Superflyweight
Jeffrey Mathebula 26-3-2 IBF Champion
Toshiaki Nishioka, Number 1 fighter at Super Bantamweight, 39-4-3, long reigning WBC champ
Jorge Acre, 4 division champion, 61-6-2 record
Vic Darch- 28-0, IBF Champion, number 1 fighter at Flyweight

 

Vicente Saldivar's run in FW title fights is impressive.

Champion Sugar Ramos who was 45-1-3 going into the fight
#2 contender Raul Rojas 23-0-1
Howard Winstone 53-2
Floyd Robertson
#1 contender Mitsunori Seki x 2 54-8-1
Howard Winstone a further x 2 59-3
#1 contender Jose Legra in a non title bout 107-6-4
The excellent Johnny Famechon 56-4-6

All victories. He beat the brilliant 34-1 Ismael Laguna in a non title bout heading into that run, too.

 

Floyd Mayweather in any of his reign

 

I can't say which is the best run, I don't know much about boxing (but it's a great topic).
Tyson's run: Trevor Berbick, James Smith, Pinklon Thomas, Tony Tucker, Larry Holmes, Tony Tubbs, and Michael Spinks.

Mike Tyson defeated 3 current, 3 former world heavyweight champions, and lineal heavyweight champion in 8 fights.
5 wins by knockout, and 2 wins by points.

And more than quality opponents.

 

Usyk's recent run at Cruiserweight was great. Every opponent from Glowacki to Bellew was of quality and majority of them He fought in their home-towns.

 

You could include future champ Bruno in there, as well.

Pretty great run. That's how you grab the world's attention. After the Spinks win, he was one of the most well-known athletes on the planet.

The first Bruno fight was originally penciled in for Wembley in the fall of 1988. That would've been epic.

 

Muhammad Ali’s second reign consisted of:
Joe Frazier
Ken Norton
Earnie Shavers
Jimmy Young
Joe Bugner
Ron Lyle

 

Fighting Harada had a relatively short, but ATG BW reign:

Won the title off a 47-0-3 Jofre
1st defense vs 23-1 Alan Rudkin
Then Jofre again
Huge punching Jose Medel, who had KO'd him 3-years earlier
Then 43-1-2 top contender Bernado Caraballo

All wins, before losing to the great Lionel Rose.