Only if it's a good fight. If Joe beats Kessler easily then people will say Kessler was overrated and the fight meant nothing.
Mayweather-Hatton. This fight has been talked about since forever, both guys are in their primes, both are undefeated, both have a lot of people picking against them, both are big names. I think that it is easily the most significant fight of all that are listed although some of the other ones may turn out to be better
Calzaghe/Kessler is definitely the most meaningful, but Mosley/Cotto has "fight of the year" potential. :good