Cotto's going to destroy Margo, who's lack of defence, slow speed and general sloppyness isn't going to work against a precise, damaging operator who will find his mark quite a bit. Cotto can nail him moving in and out, or push him back behind the jab and he won't land on Cotto like he did Cintron, the difference in class is major. Cotto TKO 5, brutality. Margo is weak to the body, something people overlook and his chin is not iron by any means. Cintron just couldn't get leverage, but Clottey and Williams buzzed him.
What power shots? He's a volume puncher with average punching power. Mayorga swung for the fences, but his power/speed was much better. His shots were much harder to see coming than Margarito's and I think his accuracy was slightly better than Margarito's.. but who's isnt? Margarito's accuracy is only a little bit better than the average Telefetura C+/B- level fighters.
Add Santos to that list, at least in the second fight. Margarito is no Mayorga, I really can't say how this fight ends, but it will b dramatic.