Margarito by late TKO. I still think Cotto's whiskers are dentable, even at this weight. It won't be easy, though. This fight is gonna be a WAR.
Cotto has the boxing skills and abilities to win a hard fought UD. With superior foot work Cotto can move laterally slipping shot winning rounds working Margos frame. I don't think it would be to Cotto's benefit to go toe to toe against the bigger, stronger Margo. The only way The Tijuana Tornado has a chance is if Cotto decides to exchange combo in the inside. Margo can quickly change the fight into his favor. Unlike the other fighters that stagered Cotto, Margo wont allow Cotto to hold and grab to recuperate. Cotto has the ability to pull a win, but it's going to take alot of will and smarts.
Cotto will make Margo look bad. Easily outboxes him and cuts Margos workrate in half by catching Margo coming in and effective counterpunching since we all know Margo leaves himself wide open. Wide UD for Cotto. Bring on Mayweather!!!!!
I am not sure right now who will win. Maybe Margo will hit Cotto square on the jaw and will put him to sleep.. But on further analysis I think Cotto will stop Margo with body shots. It will be Peñalosa vs. Gonzales all over again. Margo will fold!