You know what? Now that I think about it everytime Cotto has been seriously hurt it was when he had his opponent on the ropes. I change my pick. Santos wins by TKO. Santos would lure him in and drop him with a short left or a right hook.
I'm surprised at the amount of votes going for Cotto. Personally, as big a fan as I am of his, Santos would be tough. He's nearly six feet tall and enters the ring just over the light-heavyweight limit with an awkward southpaw style and good pop.