Depending on how far he's faded, Cotto might have trouble with Ishe's defensive skills and could drop a close decision in that matchup, though I'd still favor Cotto clearly. Molina doesn't have the pop to bother him though, and Molina's very busy style is a tough matchup for Ishe.
Both doable for Junito, and his second easiest path to another world title at 154. Baysangurov with the WBO is the sitting duck he should really go after. Less of a pain in the ass to figure out than Smith or Molina, just a class below Cotto. Lara (WBA regular), or the unified victor of Mayweather/Alvarez (WBC & WBA Super) are all out of the question. He shouldn't even be thinking about them.