It's a case where if Joe survives the first 3-4 he runs away with it. Lennox would have to start fast, if he fails he can't handle the smoke.
I'm not sure about Larry Holmes. Holmes spoke a couple years ago about how he was sparring with Joe Frazier in late 1973 to prepare Frazier for his return fight with Muhammad Ali and Joe Frazier broke Holmes' ribs during one session. Holmes was young, but that was after Frazier had been dropped six times by Foreman and lost his title at the start of that year. So Joe Frazier in 1971 against Holmes at his best might not have been so great for Larry Holmes' ribs.
Tyson Fury would do better than Holmes against Frazier hands down, Much bigger,stronger, just as fast, as smart with more power than Holmes with the same level of chin and heart