Cotto/Margarito was an epic classic. But unfortunately its not even the best fight of 08. You have to give it to Vasquez/Marquez III.
Both fighters get dropped, a lot of blood, a point deduction, non-stop, evenly matched action for 12 rounds, high level of skill, mesmerizing exchanges, and a fantastic, dramatic finish. What more do you want? Definitely one of the top 10 BEST fights I have ever seen.