That would be a similar accomplishment to what Pacquiao did to Cotto. If a former Flyweight dominating a strong WW champion is not the most impressive boxing feat in decades....
Hell, Mikey Garcia wouldn't beat Bradley/Cotto/Clottey/Mosley/Margarito/Marquez, nevermind a flyweight. But yes, that's why Pacquiao is the GOAT to me.
Hell it might even be less impressive. Crawford won his first title at 135 unlike Cotto who won his first at 140.
Would Crawford be drained and coming off a plastered beating too? That being said Inoue would never be able to beat the Cotto that Pac beat.
Even if Inoue had the best PEDS he wouldn't compete with Cotto or Crawford. Pac was just way too fast and unorthodox, that made up for the size difference. Inoue is fast but not Pac fast.
5'5 Gamboa had Crawford doing the Giuseppe spaghetti dance, and he doesn't have the type of power the monster possesses.