I'll calling it now..Khan outboxes and clowns Spence.

No question about it speed kills and Khan has the fastest hands in the game bar none. He'd light Spence up like a Christmas tree and slice him up something terrible with those laser quick, laser precision combos of his. Spence has never seen speed like that before, not in a fight, not in the gym, not in this lifetime or a previous one, or in this dimension or any other. Go ask Maidana and Paulie how fast Khan's hands are (both of them are record saying he was the fastest they ever fought). Spence is so basic. He's your typical straight up 'n down, no special effects plodder and the difference in speed of hand and foot between him and Khan is light years apart. Khan's lightning quick combos to head and body would be coming at him with such velocity and from so many different angles Spence would think he was being ambushed by a 1000 ninjas. Matrix fighters make easy work out of straight up 'n down, slug slow plodders like Spence.

It took Spence 3 rounds and over 100 flush shots to get Lo Greco out of there, a Lo Greco who who took the fight on short notice and was in the worst shape of his life, whereas Khan absolutely annihilated Lo Greco in under 40 seconds, a Lo Greco who had a full camp, was in the best shape of his life (as evidenced by the all the videos he kept posting on his social media all throughout it chronicling how well everything was going), HAD sparred over 150 rounds - including against top guys like Jesse Vargas among others, and had enlisted the services of the great Fernando Vargas to be his main trainer. And that was a Khan who had been out 2 years and was coming off a savage HL reel KO loss after eating a brutal Clenbuterol right hand bomb from 190lb Clenelo.

Both legal links from the official YT channels of PBC's and Sky Sports

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Lo Greco said that Khan hits harder than Spence and that he'd favour him to knock him out if they ever fought. Straight from the horse's mouth and when you compare their respective performances against him it certainly lends credence to his assertion.

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This isn't a difficult one to predict at all, Khan smokes him and he makes it look easy. Spence isn't seeing the 5th and if Spence ever manages to inflate his plums to take the Khan challenge I would strongly advise you to take that to the bank.