No way in hell. Mosely is done. He gave a good effort against Miguel, but he needs to hang em up. I seriously doubt Mayweather is interested in going after Cotto's leftovers. Especially considering how he always rags on Cotto for doing the same. I like Shane, but he's not even that big of a draw, he's old, and he's coming off a loss. I seriously doubt he and Mayweather will ever fight.
It this point, probably not. If Shane had beaten Cotto (I know some people think he did, but I mean officially) perhaps we may have. But there are so many other big fights out there for PBF, I don't think he would go with Shane.