Lets not forget Judah is way faster then Cotto and has the ability to protect his suspect chin his speed, defense and footwork. Margarito is pretty slow and can be sloppy by throwing wide fairly often, so I don't think this is an automatic KO or Margo victory.
Judah has decent pop but doesn't throw nearly enough. Poor stamina, bad chin and weak mentality will be a recipe for disaster against Margo.
The beating will not start untill the 5th or 6th round so I'd say Margarito KO Judah somewhere around 6,7,or 8th round.