Khan vs Mayweather is being made definatley. (2011) Its all about in house match ups at the moment. Pacquiao deals with the top ranks, and Mayweather deals with the GBP. ODLH is talking about Khan can beat Mayweather. Probably going to made in UK, and Mayweather will make Khan a big name in the US. Good business move by ODLH. Also Saul Alvarez vs Mayweather can also be a fight that makes money.
I think Khan could make it interesting if he maintains control of distance with his jab. He could conceivably win the battle of jabs as he has comparable handspeed and is younger...but I think Floyd could bait Khan into some huge counters and get Amir down on flash kd's.