Prime for Prime: Holmes via schooling. Bowe has his moments, & perhaps stuns Holmes at some point, but is largely outboxed to a clear decision (8-4/9-3). Prime Bowe vs 90s Holmes: Bowe via UD or Late Stoppage. Holmes wins the early rounds & looks good early, but fades as his gas tank & Bowe's work-rate & pressure mounts up on him.
Definitely Holmes, his jab, his movement would be too much. Bad style match up for Bowe, he doesn't even have much of a punchers chance as we all know Holmes had an iron chin and immense powers of recovery.