I don't know. Margo beat Cotto, plaster or no plaster, because he could take Cotto's best shots and keep coming forward and cutting the ring off. Margo took a hell of a lot of punishment from Pacquiao and has been in a lot of wars though so who knows what his punch resistance is like now? If he can still take the same level of punishment then yes, I think he wins the rematch.
I'll be going with Cotto all the way, I actually think Cotto will stop him late, he'll want revenge and he feels the decision should have been changed to a no contest.. To be fair I've never seen a face so badly marked after so few punches landed in a fight.. I mean for nearly all there fight it was a one sided beat down, Cotto couldn't miss him, margarito knew that his time would come though, I for one believe he should have been banned for life.. I really hope Cotto does a number on him....