I agree he needs some body recomposition. He's a HW so usually a little flab is allowed, but not if it comes along with lowered cardio. Mike Tyson was an outlier being a fully developed man at 20 (maybe even 18), Moses still needs to develop into his adult frame.
Itauma could blitz him. 1966 Ali had all he could handle against a small, light hitting Euro champ southpaw in Mildenberger. The champ from 60+ years ago would be getting hit more, harder and cleaner than he'd ever been hit in his life.
Blitz him has to be his only shot but one thing Ali was not is a frontrunner. Thats the one guy more than anyone else whose not going to let someone KO him early can you think of anyone with more endurability than Muhammad Ali? I can't.
That extra padding of fat is probably beneficial for recovery and strength though. Itauma could be lying but he says he benches, deadlifts and squats big numbers in the gym. If he cut down to 220 he would probably be both weaker and recover slower, even though he would look more ripped and fit.