I am sinister, in the original superstitious-ass Catholic sense (use my left to write; they fully believed this was the devil's work until very recently in history, as in my parents' generation) - yet was a versatile player in Little League (meaning I was a C+ utility guy off the bench at any position, as I was pedestrian throwing/batting righty and equally pedestrian lefty . Hell of a poker-faced bunter, though...) I have always felt more natural boxing orthodox. I can box southpaw, after painstaking efforts to make it stop feeling unnatural (at one point I split my training 50-50, and even went full lefty for a few months, but could never shake that sense of it being ill-fitting and somehow alien). I don't think it attributable to anything so reductive as "whatever you learn first is always going to feel better". I think if you're naturally mean to be a better fit the other way, it'll eventually bear out with practice. In my case it hasn't, but I can at least fight lefty in spurts well enough without utter embarrassment. But that honestly took a lot of work.
I think it's what shots it allows you throw most effectively. A ramrod jab with you stronger hand backed by a strong left hook that can then be followed up with a money punch of a right uppercut can make for a flashy little set. I can throw decent enough overhands from distance but they've never been my go to shots in anything other than in an actual brawl.
I'm just an ambidextrous **** who's been blessed with the ability to feel comfortable in both stances. But I still fight southpaw unless my situation calls for a switch up.
I remember being jabbed half to death before managing to inadvertently land a left hook to my opponents armpit as he was pulling his arm back. It became a very different fight as soon as his arm stiffened up!
I've seen very few guys transition (and then perform, both ways) smoothly & effortlessly a hundred percent of times without so much as one mental 'hiccup' now and then. In recent memory, perhaps only Terence Crawford and Hank Lundy.