Nargarito, is DONE, finished, OVER, reduced

None of the four fighters you mention took a validated BEATING like Margarito did last night.
None of the four fighters you mentioned were reduced to not throwing a single punch for fear of being hit, in the final, knockout, round.
You saw margarito come out in a shell in round 9, afraid to throw a punch for fear of being countered and countered HARD. Not a single punch.
Shane had beaten him into a shell.

Even when Forrest was knocked out by Mayorga, Forrest did not suffer a sustained beating wherein he was reduced to a shell, balled up and scared to fight back.
This is the man who beat Mosely twice but in no way did he give Mosley the sustained beating that Mosley gave Margarito.

I thought Hopkins was robbed in the first fight with Taylor, as did many.
Hopkins suffered no loss of courage, nor did he lose his will to fight back in either fight. Margarito did.

In short, NONE of the fighters you mention were beaten into a balled up mass of defenseless punching bags as Margarito was last night.

Up until last night Margarito got by winning fights by taking punishment.
We saw last night that you cannot win fights while using your face as fists.
Sooner or later someones gonna come along and give more than you can take........that happened. Rather than back off and say to himself, " I can't hurt this guy" Shane Mosley committed to battering Margarito with hard shots each and everytime the opportunity presented itself, and if you watch any of Margaritos fights, that opportunity presents itself early and extremely frequently.
This is what Cotto should have done, but didn't.

Margarito will fight again........it will be for money and not glory.
This fight did him in, unless something changes and he becomes a boxer with the basic fundamentals.

I doubt he will win a rematch with Cotto, but he will fight for the money.
I dont see a Paul Williams rematch taking place, ever.
The Pacman fight would be a dissection with another fighter Margarito can't hit while sustaining a beating from yet another smaller, faster hard hitting fighter.....so he won't want that fight.
I'm certain he'll think twice about calling Mayweather out ever again.

After last night, everyone and their brother will want a piece of Margarito due to knowing he's easily beatable with a sustained attack and boxing ability.
I'm sure Cotto is chomping at the bit right now.

It's over.

 

Last night was a career ending performance by Margarito.

Let us go back in time to Alexis Arguello vs Aaron pryor II
This is what you saw last night.