Well, Vazquez spars with Pacquiao even though Pacquiao is heavier, Vazquez really gets tagged a lot and thats just sparring.
I can see Pacquiao losing these fights. He is at his best now, whereas he was no where near his prime back at the very low weights.
vazquez & marquez were prime in those fights,pac wasnt half the fighter he is now when he was at 118,id actually back izzy & rafa in this match up against pac.great fights either way.
Pac pretty much bypassed 118. At 122, where the trilogy took place and where Pac dismantled Ledwaba, I'd take Pac to knock them both out. Too big, too fast, and too powerful for fighters with so-so defense like Izzy and Rafa. He himself was a bit raw then too, so both would have a decent chance of beating him as well, though I really wouldn't expect it.