A lot of targeting upstairs and sneaking in a lot of hard straight lefts to the body very early on, and I think that's what had Margarito hunched over with his power gone for the rest of the fight. Same thing happened when Pacquiao had his biggest breakout moment against Barrera the first time so long ago, Barrera was eliminated early on with the straight left to the body when Pac used his jab to force Barrera's arms upward, and Barrera spent the rest of the fight covering his body up and unable to generate any punches.