I've never heard the words "prime" and "Daniel Santos" used in the same sentence. I dunno who to even favor after reading that.
I honestly think "Southpaw" is the right stance to land against Williams. Granted dude ain't no defensive wizard, I think Margarito has better "D". Would make for a good "fantasy" scrap. In his day, Santos could defo punch & was a HUGE (body wise) fighter aswell. Since I want to agree with myself, I'm saying Santos southpaw style troubles Willy. (Just like Quintana I & Martinez I & II... I know someone is gonna pull Winky out of their ass, save it tho we all know the real there)
Santos was a cagey, awkward fighter. Alcine is no Paul Williams and the Santos that gave Margarito problems most likely gives Williams problems as well, but he wasn't as slick, powerful, or fast as Sergio. Santos was very inconsistent even in his prime and fell to fighters much inferior to Williams