Hopkins doesn't lose to lefties. Hopkins UD... maybe even a KO simply because Calzaghe is too open for the right hand.
I agree. Hopkins is also the better defensive fighter and those who pick Calzaghe and mention his superior workrate need to check out his fight with Glen Johnson. He is more than capable of matching Calzaghe's workrate. He must have been throwing 70-80 punches around in that fight, which is similar to Clazaghe's punch output.
Right now it is a mismatch. In their primes Hopkins would give Calzaghe massive problems with his right hand.