I think people are kidding themselves if they think Floyds next fight will be against Manny. Having been out of action since May 2010 and with Manny due to fight Manny 2011, it's inevitable that Floyd would have a tune up fight before fighting Manny. I also don't see him fighting Khan until 2012 the earliest.
I do believe will see Floyd in the ring, once his personal life gets under control. We may see him in the ring by the ended of next year or sooner. It's hard to say if his next opponent will be Pac considering there past encounters with one another. But if Floyd should call it quits for good, the dude shouldn't have any regrets. He's dominated since the time he turned pro and captured titles in several weight classes while remaining undefeated his whole career and made a ton of money while doing so. He can leave the sport with his head held high and swollen pockets.
Pacquiao's fighting Mosley in May. No way he fights twice in the summer. Count on Mayweather fighting in the summer and in the winter of 2011.