Just think of Cotto fighting a more faster, stronger and better stamina with non stop action version of Clottey then you can see what PAC will do.
Vasquez fights nothing like either Marquez brother. He's a brawler, the other two are boxer/punchers. Rafa is more puncher than boxer, however. And you shouldn't considering their styles are nothing alike. His hands are still considerably faster than Cotto's even if he's not as fast as he once was. The bottom line is superior timing beats speed. Your focus seems to be more on foot speed than hand speed, though.