Why zat? Mayorga is a simple pressure fighter who was winning the rounds on simply throwing punches and pressure, Mosley got lucky with the late KO. Margarito is equally aggressive, but has a better chin, more height more reach, probably more power, he'll be much bigger come fight night... you can take alot from the Mayorga fight.
Margarito also fights and wrestles out of clinches better than Mayorga, and Mosley relies heavily on clinching as a defensive mechanism or as a way to break up his opponent's rhythm. Without all that holding Mosley would be faced with fighting a full 3 minutes of every round which is a very hard thing to do against an unrelenting punching machine like Margarito.
IMO i think that the styles didn't mesh too well in that fight, maybe the tale of the tape is similar but I think, apart from that, there isn't much to go on. Margo is much more conventional.