Pacquiao also gets better as the fight goes on. The man is relentless. Pacquiao will beat Margarito like he beat Dela Hoya. It doesn't matter if Margarito uses plaster, Pacquiao will beat him.
I think Pacquiao wins for sure and I would easily lay a bet on this one. This would be an easy fight to call. You saw Pac slipping and ducking under Cotto's punches to get away from the ropes, he will do the same to Margo except easier. Pac is a better boxer than Cotto, faster both hands and feet, more durable, more stamina and more power. If Pac doesnt stop Margo from accumulation, he will outbox him. Styles makes fights, I called Mosley to beat Margo because of his speed and output, same thing here really. Margo is an open target and he wont break Pac down like he did Cotto. Pac fights the full 12 rounds, Cotto tends to lag second half of the fight if its not going his way.
Pacquiao's speed, movement, unbelievable timing, stamina, and generalship = Margarito looking stuck in the mud for 12 rounds, aside from the occasional clean shot here and there.
I think Margarito wins. Pac is fast, but he gets hit and he tends to mix it up and Margarito would appreciate that. I think Margarito's volume punching gets him the decision. I can't see either scoring a knockout.