Left hand holding the back of the opponents head + right hand smashing the front = a very good combination. Tyson, JMM and Bute spring to mind.
This content is protected also that uppercut that broke Margo's orbital bone was nasty. It looked like it missed but it shattered his face looking for some MArquez gifs but can't find em. He puts his uppercuts together like noone else.
I'm sure that if you ask Tyson Fury, he will answer you: I've experience my own uppercut and it's not a bad one But seriously, Lucian Bute.
Margarito throws a nice long range uppercut with both hands. But the master is undoubtedly Marquez. Bute's uppercut to the body is a thing of beauty as well.