Griffith was past it by then as a 33yo. Hopkins would overwhelm him with pressure a he was far more aggressive then and would throw combinations to the head and body. He would have massive advantages in reach and height, aswell as being the stronger man, Griffiths trickery would keep him in it, but he may well fade late. Hopkins late KO or widish UD
Hopkins would win an annoyingly close decision in an ugly, dull fight. Most boxing fans would score it wider than the judges.
Not against the stronger man who wants to work relentlessly inside. That also seems quite unkind to Emile relative to others around the time (esp. Monzon).
When he was practically on his deathbed? Hopkins was swarming all over opponents, cutting off the ring effortlessly and bulling inside, throwing up to 100 punches a round against durable sorts. I'm not saying he'd match that output against an elite opponent - obviously, he froze up when he fought Jones - but I don't see Griffith slowing him down on the inside, not by any means.
No, in 1966. I've sometimes hinted that cancer might have been working on tiger more than two years later when he matched Foster, but there is absolutley not proof even of that. He was hardly on his death-bed a few months before one of his career defining wins, over 15 round against reigning champion Jose Torres.