Not at this stage of his career. In his prime I would favour him over Dubois, who would be too hittable by Wilder's monstrous right and would likely mentally check out even if he wasn't knocked senseless.
5 years ago this would've been a viable fight, but the skill gap is far too wide now. I'd favor prime Wilder, but he would be susceptible to Dirty Dubois' headbutts and fouls on the inside. Not to mention that Dubois' jab could cause some serious trouble for the Bronze dosser too.
Dubois now by massacre in 3-5 rounds. Prime for Prime? Dubois would have had a good chance if he stuck a jab on him stayed disciplined and pushed him back with it. Dubois is better than a nearly 40-year-old Luis Ortiz which is Wilder's best win. I'd still make it a 50/50 simply as Wilder was a monster puncher and so bloody fast and explosive in his prime like a rangier rich man's Fabio Wardley in terms of pure power and speed with the right hand.
I would favour Dubois I dont think he moves his head alot, but has a very strong powerful jab, that I think would have Wilder going backwards where he is not as effective imo When Fury had Wilder going backwards hw wasn't as effective When Wilder first beat Stiverne, it was on the back foot and not as explosive