Not a chance. If a smooth, skilled stylist like Angel Espada couldn't survive in 3 attempts, no way a wannabe slickster like Cotto does. His lack of refined punching form doesn't take away from his effectiveness, especially when you consider how off-putting even his glancing blows were, or the fact that he had underrated footwork and ability to put himself in position to land his blows. Cotto would get backed up into the ropes like he was with Margarito, only this time he'd be facing someone with genuinely frightening power and finishing ability, rather than a glove loader with slow hands who earns his tainted stoppages through accumulation.
Cuevas is nowhere near as talented. Whilst Cotto doesn't have a great chin, he has a defence which is unlikely to get tagged all night. Judah and possibly Quintana are on the same level or better than Cuevas, but without he big punch. He has a punchers chance, yeah, but he isn't going to win more than his share.
Cotto. would win. Cuevas was light on skill. He hit hard, but, mostly one punch at a time. Also, he was always right in front of you --- a target. Unless you were scared shitless, like most of his opponents.
Cotto will be bringing much more power, strength and pressure to table though. In a way its similar to Duran-Cuevas, with Cotto obviously not as good, but similar in style. Cotto is a dangerous fighter in his own right and his jab and straighter sharper punches are going to land before Cuevas shots are able to. He can counter Cuevas's shots and land on his open defense. Plus he can control the fight with his jab Don't get me wrong Cuevas obviously has a punchers chance, just as Judah/Mosley/Torres all did and while shaking him up ultimately failed to win (although I had Mosley beating Cotto from recollection). Incidently Mosley would definately beat Cuevas Also whats to say Cotto can't break Cuevas chin/ribs/liver?
Cuevas is a better bigger puncher, but Margarito uses the jab better and is a better in fighter and ofcourse brings much much more pressure.
Cotto looks like a million bucks the first few rounds but once Cuevas starts getting him against the ropes its lights out for Cotto.